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硕士生导师
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赵旭
日期:2019-11-08 10:43:34 来源:bat365官网

赵旭,男,1983年生,药学博士,副教授,硕士生导师。2007年毕业于bat365娱乐场备用网址,获药学学士学位,2010年、2013年分别于同校获药物分析学硕士、博士学位。

2016年1月起,在bat365官网任教、从事科研工作,同年12月,被聘为bat365娱乐场备用网址副教授。2018年入选辽宁省第十二批“百千万人才工程”万人层次,获沈阳市高层次人才“拔尖人才”称号。作为课题负责人主持国家自然科学基金青年基金项目1项,主持其他省市级课题4项。相关研究成果已发表SCI论文20余篇,其中第一或通讯作者SCI论文8篇。获得沈阳市学术成果奖2项。

主要研究方向中药、功能食品药效物质基础研究;神经退行性疾病活性成分筛选及中药干预;高尿酸血症等代谢性疾病活性成分筛选及作用机制研究。

主持的科研项目含科研获奖等情况):

1.基于活性筛选和谱效表征的益智仁抗阿尔茨海默病药效物质基础研究,国家自然科学基金青年科学基金项目(负责人)

2.基于谱效表征和信号通路的栀子豉汤抗抑郁作用机制研究,中国博士后科学基金(负责人)

3.基于XOD靶点筛选中药抗高尿酸血症显效物质平台的建立与评价,辽宁省教育厅项目(负责人)

4.酸枣仁黄酮改善学习记忆的作用机制和谱效关系表征,辽宁省教育厅项目(负责人)

5.栀子豉汤抗抑郁活性成分的筛选与治疗药物的开发,天津市企业博士后创新项目择优资助计划(负责人)

6.基于多信号通路的五味子抗抑郁、改善睡眠作用机制与“组分-效应”关系研究,国家自然科学基金面上项目(参与人)

7.沈阳市自然科学学术成果三等奖(2017CGJ-A3-178,2017年,排名:1)

8.沈阳市自然科学学术成果二等奖(2016CGJ-A2-095,2016年,排名:1)

近年来发表代表性论文:

1.Xin Su,Xu Zhao*, Lina Fang, Fuqi Wang, Hongjun Wei, Development of a validated LC-MS/MS method for quantification of phosphoinositide 3 kinase inhibitor GSK2636771: application to a pharmacokinetic study in rat plasma,Journal of Pharmaceutical and Biomedical Analysis, 2020.(IF: 2.983)

2.Xu Zhao, Xin Su, Chunmei Liu, Ying Jia*, Simultaneous Determination of Chrysin and Tectochrysin fromAlpinia oxyphylla Fruits by UPLC-MS/MS and Its Application to a Comparative Pharmacokinetic Study in Normal and Dementia Rats. Molecules,2018, 23, 1702.(IF: 3.06)

3.Xu Zhao,Zhengzheng Liao,Yu Qi,Xu Shen, Kaishun Bi, Ying Jia*,Antioxidative activity of methyl amygdalinate from the seedsof Prunus persica and neuroprotective effects onAβ1-42-induced neurodegeneration models. RSC Advances, 2016, 6, 93794-93800.(IF=3.108)

4.Xu Zhao, Chunmei Liu, Mengjie Xu, Xiaolong Li, Kaishun Bi, Ying Jia*,Total lignansofSchisandra chinensis ameliorates Aβ1-42-induced neurodegeneration with cognitive impairmentin mice andprimary mouse neuronalcells. Plos One, 2016,11(4):e0152772.(IF=2.806)

5.Xu Zhao, Chunmei Liu,Yu Qi,Lina Fang,Jie Luo,Kaishun Bi, Ying Jia,Timosaponin B-II ameliorates scopolamine-induced cognitiondeficits by attenuating acetylcholinesterase activity and brain oxidative damage in mice. MetabolicBrainDisease, 2016, 31, 1455-1461.(IF=2.297)

6.Lina Fang, Qiudi Wang, Kaishun Bi,Xu Zhao*, Simultaneous Determination of Procaspase Activating Compound 1 and Permeability Markers in Intestinal Perfusion Samples and Application to a Rat Intestinal Absorption Study. Chromatographia, 2016, 79, 1659-1663. (IF=1.402)

7.Xu Zhao, Xin Mao, Xuan Xu, Xiaolong Li, Kaishun Bi, Ying Jia*, Determination and pharmacokinetics of linarin in rat plasma after intramuscular administration of linarin solution and Yejuhua injection by HPLC. Biomedical Chromatography, 2015, 29:164-166.(IF=1.729)

8.Xu Zhao, Tiancheng Ma, Chenning Zhang, Shaohuai Shi, Sijiao Cui, Kaishun Bi, Ying Jia*, Simultaneous determination of senkyunolide I and senkyunolide H in rat plasma by LC-MS: application to a comparative pharmacokinetic study in normal and migrainous rats after oral administration of Chuanxiong Rhizoma extract. Biomedical Chromatography, 2015, 29, 1297-1303.(IF=1.729)

9. Shaohuai Shi,Xu Zhao, Aijing Liu, Bing Liu, Huan Li, Bo Wu, Kaishun Bi, Ying Jia*, Protective effect of n-butanol extract from Alpinia Oxyphylla on learning and memory impairments. Physiology & Behavior, 2015, 139, 13-20.

10. Shaohuai Shi,Xu Zhao, Bing Liu, Huan Li, Aijing Liu, Bo Wu, Kaishun Bi, Ying Jia*, The Effects of Sesquiterpenes-Rich Extract of Alpinia oxyphylla Miq. on Amyloid-β-Induced Cognitive Impairment and Neuronal Abnormalities in the Cortex and Hippocampus of Mice. Oxidative Medicine and Cellular Longevity, Volume 2014, http://dx.doi.org/10.1155/2014/451802.

11. Xiaolong Li,Xu Zhao, Xuan Xu, Xin Mao, Zhi Liu, Huan Li, Lin Guo, Kaishun Bi, Ying Jia*, Schisantherin A recoversAβ-induced neurodegeneration with cognitive decline in mice. Physiology & Behavior, 2014, 132, 10-16.

12. Zhi Liu,Xu Zhao, Bing Liu, Aijing Liu, Huan Li, Xin Mao, Bo Wu, Kaishun Bi, Ying Jia*, Jujuboside A, A neuroprotective agent from semen Ziziphi Spinosae ameliorates behavioral disorders of the dementia mouse model induced by Aβ1–42. European Journal of Pharmacology, 2014, 738, 206-213.

13. Chenning Zhang,Xu Zhao, Xin Mao, Aijing Liu, Zhi Liu, Xiaolong Li, Kaishun Bi, Ying Jia*, Pharmacological evaluation of sedative and hypnotic effects of schizandrin through the modification of pentobarbital-induced sleep behaviors in mice. European Journal of Pharmacology, 2014, 744, 157-163.

14. Aijing Liu,Xu Zhao, Huan Li, Zhi Liu, Bing Liu, Xin Mao, Lin Guo, Kaishun Bi, Ying Jia*, 5-Hydroxymethylfurfural, an antioxidant agent from Alpinia oxyphylla Miq. improves cognitive impairment in Aβ1–42mouse model of Alzheimer's disease. International Immunopharmacology, 2014, 23(2), 719-725.